AVALIAÇÃO DE TERAPIAS COMBINADAS NO TRATAMENTO CIRÚRGICO DA PERI-IMPLANTITE: UMA REVISÃO INTEGRATIVA
DOI:
https://doi.org/10.24980/ucm.v13i15.6244Palavras-chave:
Peri-implantite, Periodontia, Implante dentário osseointegradoResumo
A peri-implantite é um processo inflamatório que afeta os tecidos ao redor de implantes funcionais osseointegrados, promovendo a perda progressiva do osso de suporte. Essa revisão integrativa da literatura teve como objetivo avaliar os resultados de diferentes terapias combinadas com técnicas cirúrgicas para o tratamento da peri-implantite. Foi realizada uma pesquisa da literatura nos bancos de dados PubMed e LILACS com os descritores peri-implantite e tratamento cirúrgico. Os critérios de seleção incluíram ensaios clínicos controlados e randomizados publicados nos últimos cinco anos, em inglês, com texto completo, nos quais as técnicas cirúrgicas tratavam a peri-implantite. Doze estudos atenderam aos critérios de inclusão e foram submetidos à análise. Quatrocentos e sessenta e cinco pacientes foram avaliados, em um período aproximado de acompanhamento de 12 meses. As terapias combinadas com as técnicas cirúrgicas foram o uso de proteína derivada da matriz do esmalte (EMD), tratamento com antibióticos, terapia fotodinâmica antimicrobiana, implantoplastia, jateamento de glicina e enxertos ósseos, principalmente de origem aloplástica ou xenogênica, que foram associados ou não a membranas biorreabsorvíveis e ácido ortosilícico estabilizado em colina. Com base nos resultados, as terapias combinadas com enxertos ósseos foram mais empregadas, independentemente da origem. No entanto, o material de enxerto de origem xenógena apresentou melhores resultados na porcentagem de preenchimento do defeito ósseo. Além disso, o PDME também apresentou resultados positivos quando utilizado. De acordo com a questão-problema estabelecida, as terapias combinadas associadas às técnicas cirúrgicas são mais eficazes do que as terapias cirúrgicas isoladas, e o uso de materiais de enxerto ou o PDME apresentaram os melhores resultados.
EVALUATION OF COMBINED THERAPIES IN THE SURGICAL TREATMENT OF PERI-IMPLANTITIS: AN INTEGRATIVE REVIEW
Periimplantitis is an inflammatory process that affects the tissues around osseointegrated functional implants, promoting progressive loss of supporting bone. This integrative literature review aimed to evaluate the results of different therapies combined with surgical techniques for treating peri-implantitis. A literature search was performed in PubMed and LILACS databases with periimplantitis and surgical treatment descriptors. The selection criteria included randomized controlled clinical trials published in the last five years, in English, with full text, in which surgical techniques treated peri-implantitis. Twelve studies met the inclusion criteria and were submitted for analysis. Four hundred sixty-five patients were evaluated, with a mean follow-up period of 12 months. The therapies combined with surgical techniques were the use of enamel matrix-derived protein (EMD), antibiotic therapy, antimicrobial photodynamic therapy, implantoplasty, glycine blasting, and bone grafts, mainly of alloplastic or xenogeneic origin, which were associated or not with bioresorbable membranes and choline-stabilized orthosilicic acid. Based on the results, the combined therapies with bone grafts were more employed regardless of origin. However, the grafting material of xenogenous origin showed better results in the percentage of filling of the bone defect. Moreover, PDME also showed positive results when used. According to the established problem question, combined therapies associated with surgical techniques are more effective than isolated surgical therapies, and using grafting materials or the PDME presented the best results.
Keywords: peri-implantitis; periodontics; osseointegrated dental implantation.
Referências
AGHAZADEH, A.; RUTGER PERSSON, G.; RENVERT, S. A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months. Journal Of Clinical Periodontology, v. 39, n. 7, p. 666–673, 2012. Disponível em: https://doi.org/10.1111/j.1600-051x.2012.01880.x. DOI: https://doi.org/10.1111/j.1600-051X.2012.01880.x
ALBAKER, A. M. et al. Effect of antimicrobial photodynamic therapy in open flap debridement in the treatment of peri-implantitis: A randomized controlled trial. Photodiagnosis and Photodynamic Therapy, v. 23, p. 71–74, 2018. Disponível em: https://doi.org/10.1016/j.pdpdt.2018.05.003. DOI: https://doi.org/10.1016/j.pdpdt.2018.05.003
ALJATEELI, M.; FU, J. H.; WANG, H. L. Managing peri-implant bone loss: current understanding. Clinical implant dentistry and related research, 14 Suppl 1, e109–e118. 2012. Disponível em: https://doi.org/10.1111/j.1708-8208.2011.00387.x. DOI: https://doi.org/10.1111/j.1708-8208.2011.00387.x
ASHNAGAR, S. et al. Laser treatment of peri-implantitis: a literature review. Journal of lasers in medical sciences, v. 5, n. 4, p. 153–162, Autumn 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281989/.
BARONE, A. et al. A prospective, randomized, controlled, multicenter evaluation of extraction socket preservation comparing two bovine xenografts: clinical and histologic outcomes. The International Journal of Periodontics & Restorative Dentistry, v. 33, n. 6, p. 795–802, 2013. Disponível em: https://doi.org/10.11607/prd.1690. DOI: https://doi.org/10.11607/prd.1690
BEHESHTI-MAAL, M.; VERKET, A. Implantoplasty-provoking or reducing inflammation? - a systematic scoping review. Acta Odontologica Scandinavica, v. 80, n. 2, p. 105–116, 2022. Disponível em: https://doi.org/10.1080/00016357.2021.1945142. DOI: https://doi.org/10.1080/00016357.2021.1945142
BERGLUNDH, T. et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of clinical periodontology, v. 45, Suppl 20, p. S286–S291, 2018. Disponível em: https://doi.org/10.1111/jcpe.12957. DOI: https://doi.org/10.1111/jcpe.12957
BOSSHARDT, D. D. Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels. Journal Of Clinical Periodontology, v. 35, n. 8 Suppl, p. 87–105, 2008. Disponível em: https://doi.org/10.1111/j.1600-051x.2008.01264.x. DOI: https://doi.org/10.1111/j.1600-051X.2008.01264.x
CARCUAC, O. et al. Surgical treatment of peri-implantitis: 3-year results from a randomized controlled clinical trial. Journal Of Clinical Periodontology, v. 44, n. 12, p. 1294–1303, 2017. Disponível em: https://doi.org/10.1111/jcpe.12813. DOI: https://doi.org/10.1111/jcpe.12813
CHA, J. K.; LEE, J. S.; KIM, C. S. Surgical therapy of Peri-implantitis with local minocycline: A 6-month randomized controlled clinical trial. Journal Of Dental Research, v. 98, n. 3, p. 288–295, 2019. Disponível em: https://doi.org/10.1177/0022034518818479. DOI: https://doi.org/10.1177/0022034518818479
COSTA, F. O. et al. Peri-implant disease in subjects with and without preventive maintenance: a 5-year follow-up. Journal Of Clinical Periodontology, v. 39, n. 2, p. 173–181, 2012. Disponível em: https://doi.org/10.1111/j.1600-051x.2011.01819.x. DOI: https://doi.org/10.1111/j.1600-051X.2011.01819.x
DAUBERT, D. M. et al. Prevalence and predictive factors for peri-implant disease and implant failure: a cross-sectional analysis. Journal Of Periodontology, v. 86, n. 3, p. 337–347, 2015. Disponível em: https://doi.org/10.1902/jop.2014.140438. DOI: https://doi.org/10.1902/jop.2014.140438
DEPPE, H. et al. Nonsurgical antimicrobial photodynamic therapy in moderate vs severe peri-implant defects: a clinical pilot study. Quintessence International, v. 44, n. 8, p. 609–618, 2013.
ESTEVES LIMA, R. P. et al. Is implantoplasty efficacious at treating Peri-implantitis? A systematic review and meta-analysis. Journal Of Oral and Maxillofacial Surgery: Official Journal Of The American Association Of Oral And Maxillofacial Surgeons, v. 79, n. 11, p. 2270–2279, 2021. DOI: https://doi.org/10.1016/j.joms.2021.06.015
FERREIRA, S. D. et al. Prevalence and risk variables for peri-implant disease in Brazilian subjects. Journal Of Clinical Periodontology, v. 33, n. 12, p. 929–935, 2006. DOI: https://doi.org/10.1111/j.1600-051X.2006.01001.x
FIGUERO, E. et al. Management of peri-implant mucositis and peri-implantitis. Periodontology 2000, v. 66, n. 1, p. 255–273, 2014. DOI: https://doi.org/10.1111/prd.12049
GOBBATO, L. et al. The effect of keratinized mucosa width on peri-implant health: a systematic review. The International Journal of Oral & Maxillofacial Implants, v. 28, n. 6, p. 1536–1545, 2013. DOI: https://doi.org/10.11607/jomi.3244
HALLSTRÖM, H. et al. Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: A randomized clinical trial. Journal Of Clinical Periodontology, v. 44, n. 12, p. 1285–1293, 2017. DOI: https://doi.org/10.1111/jcpe.12805
HAMMARSTRÖM, L. Enamel matrix, cementum development and regeneration. Journal of Clinical Periodontology, v. 24, n. 9 Pt 2, p. 658–668, 1997. DOI: https://doi.org/10.1111/j.1600-051X.1997.tb00247.x
HAMMARSTRÖM, L.; HEIJL, L.; GESTRELIUS, S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. Journal of Clinical Periodontology, v. 24, n. 9 Pt 2, p. 669–677, 1997. DOI: https://doi.org/10.1111/j.1600-051X.1997.tb00248.x
HING, K. A.; BEST, S. M.; BONFIELD, W. Journal of Materials Science. Materials In Medicine, v. 10, n. 3, p. 135–145, 1999. DOI: https://doi.org/10.1023/A:1008929305897
ISEHED, C. et al. Effectiveness of enamel matrix derivative on the clinical and microbiological outcomes following surgical regenerative treatment of peri‐implantitis. A randomized controlled trial. Journal of Clinical Periodontology, v. 43, n. 10, p. 863–873, 2016. DOI: https://doi.org/10.1111/jcpe.12583
ISEHED, C. et al. Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3- and 5-year follow-up. Journal of Clinical Periodontology, v. 45, n. 6, p. 744–753, 2018. DOI: https://doi.org/10.1111/jcpe.12894
ISLER, S. C. et al. Regenerative surgical treatment of peri-implantitis using either a collagen membrane or concentrated growth factor: A 12-month randomized clinical trial. Clinical Implant Dentistry and Related Research, v. 20, n. 5, p. 703–712, 2018. DOI: https://doi.org/10.1111/cid.12661
JAVED, F. et al. Clinical efficacy of antibiotics in the treatment of peri-implantitis. International Dental Journal, v. 63, n. 4, p. 169–176, 2013. DOI: https://doi.org/10.1111/idj.12034
KHAMMISSA, R. A. G. et al. Peri-implant mucositis and peri-implantitis: clinical and histopathological characteristics and treatment. Journal Of The South African Dental Association, v. 67, n. 3, p. 122, 124–6, 2012.
KHAN, A. et al. Management of Peri-implantitis lesions without the use of systemic antibiotics: A systematic review. Dentistry Journal, v. 8, n. 3, p. 106, 2020. DOI: https://doi.org/10.3390/dj8030106
LAINE, M. L. et al. IL-1RN gene polymorphism is associated with peri-implantitis. Clinical Oral Implants Research, v. 17, n. 4, p. 380–385, 2006. DOI: https://doi.org/10.1111/j.1600-0501.2006.01249.x
LANG, N. P.; BERGLUNDH, T.; ON BEHALF OF WORKING GROUP 4 OF THE SEVENTH EUROPEAN WORKSHOP ON PERIODONTOLOGY. Periimplant diseases: where are we now? - Consensus of the Seventh European Workshop on Periodontology: Periimplant diseases: where are we now? Journal of Clinical Periodontology, v. 38, p. 178–181, 2011. DOI: https://doi.org/10.1111/j.1600-051X.2010.01674.x
LASSERRE, J. F.; BRECX, M. C.; TOMA, S. Implantoplasty versus Glycine air abrasion for the surgical treatment of Peri-implantitis: A randomized clinical trial. The International Journal of Oral & Maxillofacial Implants, v. 35, n. 35, p. 197–206, 2020. DOI: https://doi.org/10.11607/jomi.6677
LIN, G.-H.; SUÁREZ LÓPEZ DEL AMO, F.; WANG, H.-L. Laser therapy for treatment of peri-implant mucositis and peri-implantitis: An American Academy of Periodontology best evidence review. Journal of Periodontology, v. 89, n. 7, p. 766–782, 2018.
LOPEZ, M. A. et al. Antimicrobial efficacy of photodynamic therapy (PDT) in periodontitis and peri-implantitis: A systematic review. Journal of Biological Regulators and Homeostatic Agents, v. 34, n. 5 Suppl. 3, p. 59- 65. Technology in Medicine, 2020.
MATARASSO, S. et al. Clinical and radiographic outcomes of a combined resective and regenerative approach in the treatment of peri-implantitis: a prospective case series. Clinical Oral Implants Research, v. 25, n. 7, p. 761–767, 2014. DOI: https://doi.org/10.1111/clr.12183
MATSUBARA, V. H. et al. Cleaning potential of different air abrasive powders and their impact on implant surface roughness. Clinical Implant Dentistry and Related Research, v. 22, n. 1, p. 96–104, 2020. DOI: https://doi.org/10.1111/cid.12875
MILLER, S.A; FORREST, J.L Enhancing your practice through evidence-based decision making: PICO, learning how to ak good questions. Journal of Evidence-based Dental Practice, v. 1, n. 2, p. 136-141, 2001. DOI: https://doi.org/10.1016/S1532-3382(01)70024-3
MORDINI, L. et al. Peri-implantitis regenerative therapy: A review. Biology, v. 10, n. 8, p. 773, 2021. DOI: https://doi.org/10.3390/biology10080773
ØEN, M. et al. The efficacy of systemic antibiotics as an adjunct to surgical treatment of peri-implantitis: a systematic review. BMC Oral Health, v. 21, n. 1, p. 666, 2021. DOI: https://doi.org/10.1186/s12903-021-02020-1
PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical Research ed.), v. 372, p. n71, 2021.
PETERSILKA, G. et al. Effect of glycine powder air-polishing on the gingiva. Journal of Clinical Periodontology, v. 35, n. 4, p. 324–332, 2008. DOI: https://doi.org/10.1111/j.1600-051X.2007.01195.x
POLYMERI, A. et al. Surgical treatment of peri-implantitis defects with two different xenograft granules: A randomized clinical pilot study. Clinical Oral Implants Research, v. 31, n. 11, p. 1047–1060, 2020. DOI: https://doi.org/10.1111/clr.13651
RASTELLI, A. N. de S. Antimicrobial photodynamic therapy (aPDT) as a disinfection and biomodulation approach in implant dentistry. Photochemistry and Photobiology, v. 97, n. 5, p. 1155–1160, 2021. Disponível em: https://doi.org/10.1111/php.13509. DOI: https://doi.org/10.1111/php.13509
RENVERT, S.; ROOS-JANSÅKER, A.-M.; PERSSON, G. R. Surgical treatment of peri-implantitis lesions with or without the use of a bone substitute-a randomized clinical trial. Journal of Clinical Periodontology, v. 45, n. 10, p. 1266–1274, 2018. DOI: https://doi.org/10.1111/jcpe.12986
ROKAYA, D. et al. Peri-implantitis update: Risk indicators, diagnosis, and treatment. European Journal of Dentistry, v. 14, n. 4, p. 672–682, 2020. DOI: https://doi.org/10.1055/s-0040-1715779
ROMEO, E. et al. Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part II: radiographic outcome. Clinical Oral Implants Research, v. 18, n. 2, p. 179–187, 2007. DOI: https://doi.org/10.1111/j.1600-0501.2006.01318.x
ROOS-JANSAKER, A.-M. et al. Nine- to fourteen-year follow-up of implant treatment. Part III: factors associated with peri-implant lesions. Journal of Clinical Periodontology, v. 33, n. 4, p. 296–301, 2006. DOI: https://doi.org/10.1111/j.1600-051X.2006.00908.x
SALVI, G. E.; COSGAREA, R.; SCULEAN, A. Prevalence and mechanisms of Peri-implant diseases. Journal of Dental Research, v. 96, n. 1, p. 31–37, 2017. DOI: https://doi.org/10.1177/0022034516667484
SCHWARZ, F. et al. Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio -Gide). The case series. Journal of Clinical Periodontology, v. 3, n. 7, p. 491-499, 2006. DOI: https://doi.org/10.1111/j.1600-051X.2006.00936.x
SCHWARZ, F. et al. Impact of the method of surface debridement and decontamination on the clinical outcome following combined surgical therapy of peri-implantitis: a randomized controlled clinical study: Surgical therapy of peri-implantitis. Journal of Clinical Periodontology, v. 38, n. 3, p. 276–284, 2011. DOI: https://doi.org/10.1111/j.1600-051X.2010.01690.x
SCHWARZ, F. et al. Combined surgical therapy of peri-implantitis evaluating two methods of surface debridement and decontamination. A two-year clinical follow up report. Journal of Clinical Periodontology, v. 39, n. 8, p. 789–797, 2012. DOI: https://doi.org/10.1111/j.1600-051X.2012.01867.x
SCHWARZ, F. et al. Four-year follow-up of combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination. Journal of Clinical Periodontology, v. 40, n. 10, p. 962–967, 2013. DOI: https://doi.org/10.1111/jcpe.12143
SCHWARZ, F. et al. Peri-implantitis. Journal of Clinical Periodontology, v. 45 Suppl 20, p. S246–S266, 2018. DOI: https://doi.org/10.1111/jcpe.12954
SEKI, K. et al. Efficacy of glycine air-powder abrasion for treatment of peri-implantitis. Journal of Dental Sciences, v. 17, n. 2, p. 1053–1055, 2022. DOI: https://doi.org/10.1016/j.jds.2021.12.016
SHIBLI, J. A. et al. Treatment of ligature-induced peri-implantitis by lethal photosensitization and guided bone regeneration: a preliminary histologic study in dogs. Journal of Periodontology, v. 74, n. 3, p. 338–345, 2003. DOI: https://doi.org/10.1902/jop.2003.74.3.338
SMEETS, R. et al. Definition, etiology, prevention and treatment of peri-implantitis--a review. Head & Face Medicine, v. 10, n. 1, p. 34, 2014. DOI: https://doi.org/10.1186/1746-160X-10-34
SOUZA, M. T. DE; SILVA, M. D. DA; CARVALHO, R. DE. Integrative review: what is it? How to do it? Einstein (Sao Paulo, Brazil), v. 8, n. 1, p. 102–106, 2010. DOI: https://doi.org/10.1590/s1679-45082010rw1134
STAVROPOULOS, A. et al. Mechanical and biological complications after implantoplasty-A systematic review. Clinical Oral Implants Research, v. 30, n. 9, p. 833–848, 2019. DOI: https://doi.org/10.1111/clr.13499
TAPIA, B. et al. The adjunctive effect of a titanium brush in implant surface decontamination at peri-implantitis surgical regenerative interventions: A randomized controlled clinical trial. Journal Of Clinical Periodontology, v. 46, n. 5, p. 586–596, 2019. Disponível em: https://doi.org/10.1111/jcpe.13095. DOI: https://doi.org/10.1111/jcpe.13095
TAKASAKI, A. A. et al. Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontology 2000, v. 51, n. 1, p. 109–140, 2009. DOI: https://doi.org/10.1111/j.1600-0757.2009.00302.x
TASTEPE, C. S. et al. Cleaning and modification of intraorally contaminated titanium discs with calcium phosphate powder abrasive treatment. Clinical Oral Implants Research, v. 24, n. 11, p. 1238–1246, 2013. DOI: https://doi.org/10.1111/j.1600-0501.2012.02536.x
TEUGHELS, W. et al. The effect of choline-stabilized orthosilicic acid in patients with peri-implantitis: an exploratory randomized, double-blind, placebo controlled study. BMC Oral Health, v. 21, n. 1, p. 485, 2021. DOI: https://doi.org/10.1186/s12903-021-01817-4
VERDUGO, F.; LAKSMANA, T.; URIBARRI, A. Systemic antibiotics and the risk of superinfection in peri-implantitis. Archives of Oral Biology, v. 64, p. 39–50, 2016. DOI: https://doi.org/10.1016/j.archoralbio.2015.12.007
WAAL, Y. C. M. et al. Implant decontamination during surgical peri-implantitis treatment: a randomized, double-blind, placebo-controlled trial. Journal Of Clinical Periodontology, v. 40, n. 2, p. 186–195, 2013. Disponível em: https://doi.org/10.1111/jcpe.12034. DOI: https://doi.org/10.1111/jcpe.12034
WANG, C.-W. et al. Laser-assisted regenerative surgical therapy for peri-implantitis: A randomized controlled clinical trial. Journal of Periodontology, v. 92, n. 3, p. 378–388, 2021. DOI: https://doi.org/10.1002/JPER.20-0040
WILTFANG, J. et al. Regenerative treatment of peri-implantitis bone defects with a combination of autologous bone and a demineralized xenogenic bone graft: a series of 36 defects: Regenerative treatment of Peri-implantitis bone defects. Clinical Implant Dentistry and Related Research, v. 14, n. 3, p. 421–427, 2012. DOI: https://doi.org/10.1111/j.1708-8208.2009.00264.x
YAMAMOTO, A.; TANABE, T. Treatment of peri-implantitis around TiUnite-surface implants using Er:YAG laser microexplosions. The International Journal of Periodontics & Restorative Dentistry, v. 33, n. 1, p. 21–30, 2013. DOI: https://doi.org/10.11607/prd.1593
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2024 Júlia de Oliveira NEVES, Otávio Augusto Pacheco VITÓRIA, Giovanna Lima FORTUNATO, José Guilherme Pereira GONÇALVES, Juliano Milanezi de ALMEIDA, Vivian Cristina Noronha NOVAES (Autor)

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.