AVALIAÇÃO DO USO DO CHÁ VERDE (CAMELLIA SINENSIS) COMO COADJUVANTE NO TRATAMENTO E CONTROLE DA DOENÇA PERIODONTAL: REVISÃO INTEGRATIVA
DOI:
https://doi.org/10.24980/ucm.v10i12.4830Palavras-chave:
Chá, Doenças Periodontais, Periodontia, Camellia sinensisResumo
Terapias coadjuvantes ao tratamento convencional da periodontite têm sido sugeridas para otimizar os resultados terapêuticos, sendo que o chá verde tem sido proposto por apresentar propriedades benéficas ao tratamento periodontal. Nesse contexto, o objetivo desta revisão integrativa foi avaliar se o uso do chá verde é eficaz no tratamento e controle da periodontite. Para isso, foi realizado um levantamento bibliográfico nas bases de dados PubMed, Lilacs e Cochrane Library, com os descritores green tea, periodontal disease, Camellia sinensis e periodontitis. Foram selecionados artigos na língua inglesa publicados nos últimos 10 anos em que o chá verde deveria ser obrigatoriamente empregado como uma conduta terapêutica e incluídos estudos clínicos randomizados controlados e revisões sistemáticas. Foram excluídos ensaios pré-clínicos, relato de caso clínico, série de relatos clínicos, estudos epidemiológicos, editoriais, opiniões de especialistas, estudo piloto, revisões de literatura, pesquisas com resultados inconcludentes e estudos in-vitro. A busca resultou em 450 artigos dos quais, após aplicação dos critérios de inclusão e exclusão, selecionaram-se 10 artigos, sendo 8 ensaios randomizados controlados e 2 revisões sistemáticas com meta-análise. 6 artigos avaliaram a efetividade do chá verde como colutório oral demonstrando redução da inflamação e do acúmulo de placa bacteriana, 3 estudos associaram o chá verde a raspagem e alisamento radicular, demonstrando diminuição da profundidade, sangramento a sondagem e redução do quadro inflamatório e 1 estudo avaliou a ingestão sistêmica, demonstrando redução na profundidade de sondagem e sangramento. Dessa forma, podemos concluir que o chá verde é eficaz como terapia coadjuvante no tratamento e controle da periodontite. Quando associado à raspagem e ao alisamento radicular e como colutório oral, apresentam-se resultados mais satisfatórios que na forma de ingestão oral.
ASSESSMENT OF GREEN TEA (CAMELLIA SINENSIS) USED AS AN ADJUNCT TO TREATMENT AND CONTROL OF PERIODONTAL DISEASE: INTEGRATIVE REVIEW
Adjunct therapies to conventional treatment for periodontitis have been suggested to optimize therapeutic results; green tea has been suggested because it presents beneficial properties for periodontal treatment. In this context, this integrative review aims at assessing the effectiveness of green tea for periodontitis treatment and control. Thus, bibliographic research was carried out in PubMed, LILACS, and Cochrane Library databases, using the words green tea, periodontal disease, Camelliasinensis, and periodontitis as keywords. Articles in English language issued in the last 10 years were screened, in which green tea was imperatively used as a therapeutic approach and included randomized controlled trials and systematic reviews. Pre-clinical trials, clinical case reports, series of case reports, epidemiological studies, editorials, expert opinions, pilot study, literature review, researches with inconclusive results, and in-vitro studies were excluded. The search resulted in 450 articles in which, after applying inclusion and exclusion criteria, 10 articles were screened, being 10 articles, 8 randomized controlled trials, and 2 systemic reviews and meta-analysis. 6 articles assessed the effectiveness of green tea as mouthwash and presenting a reduction either in inflammation and the accumulation of bacterial plaque, 3 studies associated green tea to scaling and root planing, indicating a decrease in the depth, bleeding when drilling, and reduction in the inflammatory process, 1 study assessed the systemic intake, indicating a reduction in drilling depth and bleeding. Thus, we can conclude that green tea is efficient as adjuvant therapy to the treatment and control of periodontitis. When associated with scaling and root planing, and used as a mouthwash, the results were more satisfactory when it was used as a mouthwash than when it was ingested.
Keywords: Tea. Camelliasinensis. Periodontal Diseases. Periodontology.
Referências
ADDY, M.; MORAN, J. Comparison of plaque accumulation after topical application and mouth rinsing with chlorhexidine gluconate. Journal of Clinical Periodontology, v. 10, ed. 1, p. 69-71, Jan 1983. Disponível em: https://pubmed.ncbi.nlm.nih.gov/6572636/. Acesso em: 10 nov. 2020.
AHMED, S. et al. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. The journal of pharmacology and experimental therapeutics, v. 3008, ed. 2, p. 737-773, Fev. 2004.Disponível em: https://jpet.aspetjournals.org/content/308/2/767.long. Acesso em: 20 nov. 2020.
ALBERTO, F. B. et al. Estudio de las propiedades antimicrobianas de la Camellia Sinensisen Un modelo microbiano oral. Odontología (Ecuad.), v. 19, ed. 1, p. 33-41, 2017. Disponível em: https://docs.bvsalud.org/biblioref/2019/05/996609/33-41.pdf. Acesso em: 7 dez. 2020.
APOLINÁRIO, R.S. et al. Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience. The International Journal of Pharmaceutical Compounding, v. 22, ed. 6, p. 512-515, 2018. Disponível em: https://ijpc.com/Abstracts/Abstract.cfm?ABS=4546. Acesso em: 7 dez. 2020.
ARAGHIZADEH, A.; KOHANTEB, J.; FANI, M. M. Inhibitory activity of green tea (Camellia sinensis) extract on some clinically isolated cariogenic and periodontopathic bacteria. Medical Principles and Practice, v. 22, ed. 4, p. 368–372, Jun-2013. DOI 10.1159/000348299. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586764/. Acesso em: 13 out. 2020.
AWADALLA, H. I. et al. A pilot study of the role of green tea use on oral health. International Journal of Dental Hygiene, v. 9, ed. 2, p. 11-116, Mai 2011. Disponível em: https://doi.org/10.1111/j.1601-5037.2009.00440.x. Acesso em: 9 nov. 2020.
BALAPPANAVAR, A.; SARDANA, V; SINGH, M. Comparison of the effectiveness of 0.5% tea, 2% neem and 0.2% chlorhexidine mouthwashes on oral health: A randomized control trial. Indian Journal of Dental Research, v. 24, ed. 1, p. 26-34, 2013. Disponível em: https://www.ijdr.in/article.asp?issn=0970-9290;year=2013;volume=24;issue=1;spage=26;epage=34;aulast=Balappanavar. Acesso em: 9 ago. 2020.
BANSAL, M. et al. Impact of Different Antioxidants on the Bond Strength of Resin based Composite on Bleached Enamel-An In Vitro Study. Journal of Contemporary Dental Practice, v. 20, ed. 1, p. 64-70, 2019. Disponível em: https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01936807/full?highlightAbstract=tea%7Cperiodont%7Cgreen%7Cperiodontitis. Acesso em: 10 nov. 2020.
BONESVOLL, P.; GJERMO, P. A comparision between chlorhexidine and some quaternary ammonium compounds with regard to retention, salivary concentration and plaque-inhibiting effect in the human mouth after mouth rinses. Archivesof Oral Biology, v. 23, ed. 4, p. 289-294, 1978. DOI 10.1016/0003-9969(78)90021-3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/278566/. Acesso em: 30 out. 2020.
BRECX, M. Strategies and agents in supragingival chemical plaque control. Periodontology 2000, v. 15, p. 100-108, Out. 1997. DOI 10.1111/j.1600-0757.1997.tb00109.x. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0757.1997.tb00109.x?sid=nlm%3Apubmed. Acesso em: 3 nov. 2020.
CARDOSO, K. B. et al. Short-term evaluation of a green tea extract-based mouthrinse. SALUSVITA, Bauru, v. 35, n. 1, p. 41-51, 2016. Disponível em: secure.unisagrado.edu.br/static/biblioteca/salusvita/salusvita_v35_n1_2016_art_03.pdf. Acesso em: 09 ago. 2020.
CASARIN, M. et al. Melaleuca alternifolia and its application against dental plaque and periodontal diseases: A systematic review. Phytotherapy Research, v. 32, ed. 2, p. 230-240, Feb 2018. DOI 10.1002/ptr.5974. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5974. Acesso em: 14 dez. 2020.
CHAVA, V. K.; VEDULA, B. D. Thermo‐Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis: A 4‐Week Clinical Trial. Journal of Periodontology, v. 84, ed. 9, p. 1290-1296, Set-2013. Disponível em: https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2012.120425. Acesso em: 09 ago. 2020.
CHOPRA, A. et al. Green Tea Intake as an Adjunct to Mechanical Periodontal Therapy for the Management of Mild to Moderate Chronic Periodontitis: A Randomized Controlled Clinical Trial. Oral Health and Preventive Dentistry, v. 14, ed. 4, p. 293-303, 2016. DOI 10.3290/j.ohpd.a36100. Disponível em: https://ohpd.quintessenz.de/index.php?doc=abstract&abstractID=36100/. Acesso em: 27 out. 2020.
DE ALMEIDA, J. et al. Influence of adjuvant ttherapy with greentea extract in the treatment of experimental periodontitis. Archive sof Oral Biology, v. 102, p. 65-73, Jun 2019. DOI 10.1016/j.archoralbio.2019.03.028. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S000399691830668X?via%3Dihub. Acesso em: 9 dez. 2020.
GARLET, G. P. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. Journal of Dental Research, v. 89, ed. 12, p. 1349-1363, Dez 2010. DOI 10.1177/0022034510376402. Disponível em: https://journals.sagepub.com/doi/10.1177/0022034510376402?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&. Acesso em: 11 nov. 2020.
GARTENMANN, S. J. et al. The effect of green tea as an adjunct to scaling and root planing in non-surgical periodontitis therapy: a systematic review. Clinical Oral Investigations, v. 23, p. 1-20, 2019. Acesso em: 9 ago. 2020.DOI https://doi.org/10.1007/s00784-018-2684-7. Disponível em: https://link.springer.com/article/10.1007/s00784-018-2684-7. Acesso em: 9 ago. 2020.
GENNARO, G. Análise da presença de citocinas no periodonto de ratos diabéticos tratados com chá verde. 2012. 170 f. Tese (Doutorado em Odontologia) Faculdade de Odontologia de Bauru, Universidade de São Paulo, USP, Bauru, 2012. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-866469. Acesso em: 11 nov. 2020.
GJERMO, P; BAASTAD, K.L; RÖLLA, G. The plaque inhibiting capacity of 11 antibacterial compounds. Journal of Periodontal Research, v. 5, ed. 2, p. 102-109, 1970. DOI 10.1111/j.1600-0765.1970. tb00700.x. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0765.1970.tb00700.x?sid=nlm%3Apubmed. Acesso em: 21 out. 2020.
GRAVES, D. T.; LI, J.; COCHRAN, D. L. Inflammation and uncoupling as mechanisms of periodontal bone loss. Journal of Dental Research, v. 90, ed. 2, p. 143-153, Fev 2011. DOI 10.1177/0022034510385236. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144100/. Acesso em: 27 nov. 2020.
GRAZIANI, F. et al. Dental plaque, gingival inflammation and tooth -discolouration with different commercial -formulations of 0.2% chlorhexidine rinse: a double-blind randomised controlled clinical trial. Oral Health & Preventive Dentistry, v. 13, ed. 2, p. 101-111, 2015. DOI 10.3290/j.ohpd.a32827. Disponível em: https://www.quintessence-publishing.com/deu/en/article/841911. Acesso em: 21 out. 2020.
HATTARKI, S. A.; PUSHPA, S.P; BHAT, K. Evaluation of the efficacy of green tea catechins as an adjunct to scaling and root planing in the management of chronic periodontitis using PCR analysis: A clinical and microbiological study. Journal of Indian Society of Periodontology, v. 17, ed. 2, p. 204-209, Mar-Abr 2013. DOI PMCID: PMC3713752 PMID: 23869127 Ev. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713752/. Acesso em: 19 nov. 2020.
HAGHIGHATDOOST, F.; HARIRI, M. The effect of green tea on inflammatory mediators: A systematic review and meta-analysis of randomized clinical trials. Phytotherapy Research, v. 33, ed. 9, p. 2274-2287, Set 2019. DOI doi: 10.1002/ptr.6432. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6432. Acesso em: 18 nov. 2020.
HAN, K.; HWANG, E.; PARK, J. Excessive Consumption of Green Tea as a Risk Factor for Periodontal Disease among Korean Adults. Nutrients, v. 2016, n. 7, ed. 8, p. 408, Jul-2016. DOI 10.3390/nu8070408. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963884/. Acesso em: 26 nov. 2020.
HEDGE, R. J.; KAMATH, S. Comparison of the Streptococcus mutans and Lactobacillus colony count changes in saliva following chlorhexidine (0.12%) mouth rinse, combination mouth rinse, and green tea extract (0.5%) mouth rinse in children. Journal India Society Periodontics and Preventive Dentistry, v. 35, ed. 2, p. 150-155, 2017. DOI 10.4103/JISPPD.JISPPD_13_17. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28492194/. Acesso em: 11 nov. 2020.
HRISHI, T.S. et al. Effect of adjunctive use of green tea dentifrice in periodontitis patients - A Randomized Controlled Pilot Study. International Journal of Dental Hygiene, v. 14, ed. 3, p. 178-183, Ago 2016. DOI 10.1111/idh.12131. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1111/idh.12131. Acesso em: 15 dez. 2020.
HU, J. et al. The safety of green tea and green tea extract consumption in adults - Results of a systematic review. Regulatory Toxicology and Pharmacology, v. 95, p. 412-433, Jun-2018. DOI https://doi.org/10.1016/j.yrtph.2018.03.019. Disponível em: https://www.sciencedirect.com/science/article/pii/S0273230018300928?via%3Dihub. Acesso em: 19 nov. 2020.
JENABIAN, N. et al. The effect of Camellia Sinensis (green tea) mouthwash on plaque-induced gingivitis: a single-blinded randomized controlled clinical trial. Journal of Pharmaceutical Sciences, v. 20, ed. 1, p. 39, Set-2012. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555773/. Acesso em: 09 ago. 2020.
JENKINS, S.; ADDY, M.; WADE, W. The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. Journal of Clinical Periodontology, v. 15, ed. 7, p. 415-424, Ago 1988. DOI 10.1111/j.1600-051x.1988.tb01595.x. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-051X.1988.tb01595.x?sid=nlm%3Apubmed. Acesso em: 18 nov. 2020.
KAMATH, N. P.et al. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children.European Archives of Paediatric Dentistry, v. 21, ed. 1, p. 61-66, Feb 2020. DOI 10.1007/s40368-019-00445-5. Disponível em: https://link.springer.com/article/10.1007%2Fs40368-019-00445-5. Acesso em: 11 nov. 2020.
KARYGIANNI, L. et al. Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms. Frontiers in Microbiology, v. 6, p. 1529, 2016. Disponível em: 10.3389/fmicb.2015.01529. Acesso em: 11 nov. 2020.
KAUR, H.; JAIN, S.; KAUR, A. Comparative evaluation of the antiplaque effectiveness of green tea catechin mouthwash with chlorhexidine gluconate. Journal of India Society of Periodontology, v. 18, ed. 2, p. 178-182, 2014. DOI 10.4103/0972-124X.131320. Disponível em: https://www.researchgate.net/publication/262695637_Comparative_evaluation_of_the_antiplaque_effectiveness_of_green_tea_catechin_mouthwash_with_chlorhexidine_gluconate. Acesso em: 11 nov. 2020.
KHAN, N.; MUKHTAR, H. Tea Polyphenols in Promotion of Human Health. Nutrients, v. 11, ed. 1, p. 39, Jan-2019. DOI 10.3390/nu11010039. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356332/. Acesso em: 8 dez. 2020.
KHURSHID, Z. et al. Green Tea (Camellia Sinensis): Chemistry and Oral Health. The Open Dentistry Journal, v. 10, p. 166-173, 16 maio 2016. DOI 10.2174/1874210601610010166. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911733/. Acesso em: nov. 2020.
KIM-PARK, W. K. et al. Green tea catechin inhibits the activity and neutrophil release of Matrix Metalloproteinase-9. Journal of Traditional and Complementary Medicine, v. 6, ed. 4, p. 343-346, Out. 2016. DOI 10.1016/j.jtcme.2015.02.002. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067860/. Acesso em: 20 nov. 2020.
KOU, Y. et al. Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols. Journal of Periodontology, v. 79, n. 1, p. 174-180, 2008. DOI 10.1902/jop.2008.070364. Disponível em: https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2008.070364. Acesso em: 22 nov. 2020.
KUDVA, P; TABASUM, S. T; SHEKHAWAT, N. K. Effect of green tea catechin, a local drug delivery system as an adjunct to scaling and root planing in chronic periodontitis patients: A clinic microbiological study. Journal of Indian Society of Periodontology, v. 15, ed. 1, p. 39-45, Jan-Mar 2011. DOI 10.4103/0972-124X.82269. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134045/. Acesso em: 13 out. 2020.
KUSHIYAMA, M. et al. Relationship between intake of green tea and periodontal disease. Journal of Periodontology, v. 2009, n. 3, ed. 80, p. 372-377, Mar-2009. DOI 10.1902/jop.2009.080510. Disponível em: https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2009.080510. Acesso em: 3 nov. 2020.
LAGHA, A. B. et al. Green tea polyphenols enhance gingival keratinocyte integrity and protect against invasion by Porphyromonas gingivalis. Pathogens and Disease, v. 76, ed. 4, Jun. 2018. DOI 10.1093/femspd/fty030. Disponível em: https://academic.oup.com/femspd/article/76/4/fty030/4961135. Acesso em: 20 nov. 2020.
LIN, Y. S. et al. Factors affecting the levels of tea polyphenols and caffeine in tea leaves. Journal of Agricultural and Food Chemistry, v. 51, ed. 7, p. 1864–1873, 4 mar. 2003. DOI https://doi.org/10.1021/jf021066b. Disponível em: https://pubs.acs.org/doi/10.1021/jf021066b#. Acesso em: 9 ago. 2020.
MAKIMURA, M. et al. Inhibitory effect of tea catechins on collagenase activity. Journal of Periodontology, v. 64, ed. 7, p. 630-636, Jul 1993. DOI 10.1902/jop.1993.64.7.630. Disponível em: https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.1993.64.7.630. Acesso em: 12 nov. 2020.
MARUYAMA, T. et al. Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Archivesof Oral Biology, v. 56, ed. 1, p. 48-53, Jan. 2011. DOI 10.1016/j.archoralbio.2010.08.015. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(10)00257-8. Acesso em: 20 nov. 2020.
MATHUR, A. et al. Efficacy of green tea-based mouthwashes on dental plaque and gingival inflammation: A systematic review and meta-analysis. Indian Journal of Dental Research, v. 29, ed. 2, p. 225-232, 2018. Disponível em: https://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=2;spage=225;epage=232;aulast=Mathur. Acesso em: 9 ago. 2020.
MUKHTAR, H. et al. Tea components: Antimutagenic and anticarcinogenic effects. Preventive Medicine, v. 21, ed. 3, p. 351-360, 1992. DOI 10.1016/0091-7435(92)90042-g. Disponível em: https://pubmed.ncbi.nlm.nih.gov/1614996/ . Acesso em: 11 nov. 2020.
OHISHI, T. et al. Anti-inflammatory Action of Green Tea. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, v. 15, ed. 2, p. 74-90, 2016. Disponível em: https://air.unimi.it/handle/2434/235313#.YAWFW8PPzDc. Acesso em: 11 nov. 2020.
PAVEL, L; PAVEL, S. Usefulness of micronutrients in the treatment of periodontitis. Tijdschrift Voor Tandheelkunde, v. 117, ed. 2, p. 103-106, 2010. DOI https://doi.org/10.5177/ntvt2010.02.08143. Disponível em: https://www.cochranelibrary.com/central/doi/10.1002/central/CN-00735188/full?highlightAbstract=tea%7Cperiodont%7Cgreen%7Cperiodontitis. Acesso em: 10 nov. 2020.
PRIOR, R.L; CAO, G. Antioxidant capacity and polyphenolic components of teas: implications for altering in vivo antioxidant status. Proceedings of the Society for Experimental Biology and Medicine, v. 220, ed. 4, p. 255-261, Abr-1999. Disponível em: https://pubmed.ncbi.nlm.nih.gov/10202399/. Acesso em: 19 nov. 2020.
RADAFSHAR, G. et al. Effects of green tea (Camellia sinensis) mouthwash containing 1% tannin on dental plaque and chronic gingivitis: a double-blinded, randomized, controlled trial. Journal of Investigative and Clinical Dentistry, v. 8, ed. 1, p. e12184, Fev-2017. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1111/jicd.12184. Acesso em: 09 Ago. 2020
RATTANASUWAN, K. et al. Clinical effect of locally delivered gel containing green tea extract as an adjunct to non-surgical periodontal treatment. Odontology, v. 104, p. 89-97, 2016.
SAKANAKA, S. et al. Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis. Journal Bioscience, Biotechnology and Biochemistry, v. 60, ed. 5, p. 745-749, 1996. DOI 10.1271/bbb.60.745. Disponível em: https://www.tandfonline.com/doi/abs/10.1271/bbb.60.745. Acesso em: 20 nov. 2020.
SARIN, S. et al. Preliminary Clinical Evidence of the Antiplaque, Antigingivitis Efficacy of a Mouthwash Containing 2% Green Tea - A Randomised Clinical Trial. Oral Health and Preventive Dentistry, v. 13, ed. 3, p. 197-203, 16 jun. 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25610918/. Acesso em: 09 Ago. 2020.
SHAHAKBARI, R. et al. Effectiveness of green tea mouthwash in comparison to chlorhexidine mouthwash in patients with acute pericoronitis: a randomized clinical trial. International Journal of Oral and Maxillofacial Surgery, v. 43, ed. 11, p. 1394-1398, Nov 2014. DOI https://doi.org/10.1016/j.ijom.2014.05.017. Disponível em: https://www.ijoms.com/article/S0901-5027(14)00210-0/fulltext. Acesso em: 28 out. 2020.
SHALINI, M.; RAMESH, A. Comparison of anti-plaque efficacy of green tea, herbal, and chlorhexidine mouthrinse in patients undergoing orthodontic treatmen. Drug Invention Today, v. 10, ed. 8, p. 1323-1327, Ago 2018. Disponível em: https://www.researchgate.net/publication/327046563_Comparison_of_anti-plaque_efficacy_of_green_tea_herbal_and_chlorhexidine_mouthrinse_in_patients_undergoing_orthodontic_treatment. Acesso em: 10 nov. 2020.
SHETTY, S. K. et al. Compare the effcacy of two commercially available mouthrinses in reducing viable bacterial count in dental aerosol produced during ultrasonic scaling when used as a preprocedural rinse. The Journal Contemporary Dental Practice, v. 14, ed. 5, p. 848-851, Set. 2013. DOI 10.5005/jp-journals-10024-1414. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24685786/. Acesso em: 8 dez. 2020.
TAHANI, B; SABZIAN, R. Effect of Camellia sinensis plant on decreasing the level of halitosis: A systematic review. Dental Research Journal, v. 15, ed. 6, p. 379-384, 2018. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243810/. Acesso em: 11 nov. 2020.
TALEGHANI, F et al. Impact of Green tea intake on clinical improvement in Chronic Periodontitis: a Randomized Clinical Trial. Journal of Stomatology Oral and Maxillofacial Surgery, v. 119, ed. 5, p. 365-368, Nov-2018. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S2468785518300855?via%3Dihub. Acesso em: 9 ago. 2020.
THITIMUTA, S. et al. Camellia sinensis L. Extract and Its Potential Beneficial Effects in Antioxidant, Anti-Inflammatory, Anti-Hepatotoxic, and Anti-Tyrosinase Activities. Molecules, v. 22, ed. 3, p. 401, 4 mar. 2017. DOI 10.3390/molecules22030401. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155403/. Acesso em: 11 nov. 2020.
UMEDA, M. et al. Effects of nonsurgical periodontal therapy on the microbiota. Periodontology 2000, v. 36, p. 98-120, 2004. DOI 10.1111/j.1600-0757.2004.03675.x. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0757.2004.03675.x?sid=nlm%3Apubmed. Acesso em: 11 nov. 2020.
YUN, J. et al. Inhibitory effects of green tea polyphenol (–) epigallocatechin gallate on the expression of matrix metalloproteinase‐9 and on the formation of osteoclasts. Journal of Periodontal Research, v. 39, ed. 5, p. 300-307, Out. 2004. DOI 10.1111/j.1600-0765.2004.00743.x. Disponível em: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0765.2004.00743.x?sid=nlm%3Apubmed. Acesso em: 11 nov. 2020.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2021 Otávio Augusto Pacheco VITÓRIA, Juliano Milanezi de ALMEIDA, Vivian Cristina Noronha NOVAES
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
